Acetic Anhydride → HCID 14770823, compound

HRID 1651598Notes

Reaction equation

HRID 1651598 reaction equation
Cl.[C:2]([C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH:17]=2)=[C:7]([F:18])[CH:6]=1)([OH:4])=[O:3].[C:19](OC(=O)C)(=[O:21])[CH3:20]>>[C:2]([C:5]1[C:10]([F:11])=[CH:9][C:8]([C:12]2[CH2:17][CH2:16][N:15]([C:19](=[O:21])[CH3:20])[CH2:14][CH:13]=2)=[C:7]([F:18])[CH:6]=1)([OH:4])=[O:3]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 14770822HCID 14770822, compound

Product 1

HCID 14770823HCID 14770823, compound

Procedure

A suspension of 8.51 g (29.1 mmol) 4-(4-carboxy-2,5-difluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride in 90 ml acetic anhydride was stirred at reflux for 0.75 hour. The resulting solution was evaporated to dryness and the residue stirred with water, filtered, and crystallized from acetic acid-water to afford the title compound, mp 241°-242° C.

Workup

  1. temperatureat reflux for 0.75 hour
  2. customThe resulting solution was evaporated to dryness
  3. stirringthe residue stirred with water
  4. filtrationfiltered
  5. customcrystallized from acetic acid-water

Sources & evidence

ORD record
ord-d2c3cf6607ab47dd9b43f1098fde6cc7
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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