p-Toluenesulfonic acid → HCID 14770819, compound

Participants

Reaction Steps

A solution of 11.12 g (30.5 mmol) 4-(4-bromo-2,5-difluorophenyl)-1-ethoxycarbonyl-4-piperidinol and 0.70 g of p-toluenesulfonic acid in 200 ml toluene was refluxed with a Dean-Stark trap for 16 hours. The mixture was cooled, extracted with sodium bicarbonate solution, dried (MgSO4), evaporated and the residue flash chromatographed on a column of silica gel to afford a syrup which crystallized on standing, mp 40°-44° C.

Provenance & Evidence