HCID 14770868, compound → HCID 53647345, compound

HRID 1651603Notes

Reaction equation

HRID 1651603 reaction equation
[C:1]([N:4]1[CH2:9][CH:8]=[C:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(OC(=O)C)(=O)C.C(OCC)(OCC)OCC>[C:1]([N:4]1[CH2:5][CH:6]=[C:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17](=[O:24])[C:18](=[CH:22][O:21][CH2:19][CH3:18])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:12]([F:25])[CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 14770868HCID 14770868, compound

Product 1

HCID 53647345HCID 53647345, compound

Reagents, catalysts & solvents 2

HCID 7918Acetic AnhydrideSolventHCID 31214Ethyl orthoformateSolvent

Procedure

A solution of 3.95 g (11.25 mmol) ethyl 4-(1-acetyl-1,2,3,6-tetrahydro-4-pyridyl)-2,5-difluoro-β-oxobenzenepropionate in 25 ml of acetic anhydride and 2.8 ml of triethyl orthoformate was refluxed 1.5 hours. The title compound was isolated as a syrup after evaporation under vacuum in an oil bath at 80° C.

Sources & evidence

ORD record
ord-02fdd177605842af85625e93e74763de
Source dataset
uspto-grants-1990_05
Patent number
US04929613

Reaction notes

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