4-[(4-Bromobenzene)sulfonyl]morpholine → 7-Difluoromethyl-3-[4-(morpholine-4-sulfonyl)-phenylethynyl]-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

HRID 165162Notes

Reaction equation

HRID 165162 reaction equation
[Br:25][c:26]1[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[N:35]2[CH2:36][CH2:37][O:38][CH2:39][CH2:40]2)[cH:30][cH:31]1.[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[CH:13])[F:24]>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[C:13][c:26]1[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[N:35]2[CH2:36][CH2:37][O:38][CH2:39][CH2:40]2)[cH:30][cH:31]1)[F:24]

Participants

3

Reactant 2

HCID 2531284-[(4-Bromobenzene)sulfonyl]morpholineHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 118529367-Difluoromethyl-3-[4-(morpholine-4-sulfonyl)-phenylethynyl]-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Sources & evidence

ORD record
ord-8b2190db53ce44d1be119f3f969ef9a2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…