Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 70359873, compound

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Reaction Steps

A mixture of (2R,4S)-4-t-butyldimethylsiloxymethyl -2-methyl-1,3-dioxan-5-one (2.50 g) and carboethoxymethylenetriphenylphosphorane (4.00 g) in tetrahydrofuran (25 ml) was stirred at room temperature for 24 hours and the solvent was evaporated in vacuo. The residue was chromatographed on a silica gel column (50 g) with a mixture of n-hexane and ethyl acetate (10:1) as an eluent to give (2R,4R)-4-t-butyldimethylsiloxymethyl-5-ethoxycarbonylmethylene-2-methyl-1,3-dioxane (2.09 g) as an oil.

Provenance & Evidence