HCID 70359873, compound → HCID 14621461, compound

Participants

Reaction Steps

A solution of (2R,4R)-4-t-butyldimethylsiloxymethyl -5-ethoxycarbonylmethylene-2-methyl-1,3-dioxane (17.0 g) in ethanol (170 ml) was shaken under hydrogen (3 atm) with 10% palladium on carbon at room temperature for 1.5 hours. After removal of the catalyst by filtration, the solvent was evaporated in vacuo and the residue was chromatographed on a silica gel column (500 g) with a mixture of n-hexane and ethyl acetate (20:1) as an eluent to give (2R,4R,5S)-4-t-butyldimethylsiloxymethyl-5 -ethoxycarbonylmethyl-2-methyl-1,3-dioxane (9.52 g) as a pale yellow oil.

Provenance & Evidence