反应详情

温度

90 °C

Combine 2-methylbenzaldehyde (39.6 g, 0.33 mol) and malonic acid (34.3 g, 0.33 mol). Heat at 90° C. for one hour, add 3.9 g of the aldehyde, and heat 6 hr. at 90°. Allow to cool, partition between diethyl ether and 1N NaOH, acidify the aqueous layer, filter off the solid, wash and dry to give the title compound as a beige solid, m.p. 197°-200°.

1. temperatureheat 6 hr
2. customat 90°
3. temperatureto cool
4. custompartition between diethyl ether and 1N NaOH
5. filtrationfilter off the solid
6. washwash
7. customdry