4-Methyloxybenzyl chloride → 1-(2-Thiazolylmethyl)-2,2'-bi-1H-imidazole

HRID 1651754Notes

Reaction equation

Br[CH2:2][C:3]1[S:4][CH:5]=[CH:6][N:7]=1.COC1C=CC(CCl)=CC=1.[NH:18]1[CH:22]=[CH:21][N:20]=[C:19]1[C:23]1[NH:24][CH:25]=[CH:26][N:27]=1>>[S:4]1[CH:5]=[CH:6][N:7]=[C:3]1[CH2:2][N:18]1[CH:22]=[CH:21][N:20]=[C:19]1[C:23]1[NH:27][CH:26]=[CH:25][N:24]=1

Participants

Reactant 3

HCID 699934-Methyloxybenzyl chloride

HCID 1014632,2'-Biimidazole

HCID 151114782-(Bromomethyl)thiazole

Product 1

HCID 151358031-(2-Thiazolylmethyl)-2,2'-bi-1H-imidazole

Procedure

If the procedure of Example 1 is repeated using 2- bromomethylthiazole rather than 4-methoxybenzyl chloride of Example 1, the products obtained are title compounds (7) and (8).

Workup

customthe products obtained

Sources & evidence

ORD record: ord-f8ab6f42d6484d42a4952ca3bb945fe9
Source dataset: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04929744

Reaction notes

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