HCID 23050510, compound → HCID 23050449, compound

Participants

Reaction Steps

A solution of 7.1 g (26.4 mmol) of 4-(1-ethoxyethoxy)-1-(4-chlorophenyl)-2-butyn-1-ol in 40 ml of methylene chloride was added dropwise at 0° to a suspension of 68 g (0.78 mol) of manganese dioxide in 110 ml of methylene chloride. The reaction mixture was stirred at 0° for lo minutes, filtered over magnesium sulphate and concentrated. Chromatography of the residue on 300 g of silica gel (elution agent ether/hexane 1:1) yielded 4-(1-ethoxyethoxy)- 1-(4-chlorophenyl)-2-butyn-1-one as an oil.

Provenance & Evidence