HCID 23050514, compound → HCID 23050451, compound

Participants

Reaction Steps

A solution of 9.3 g (37 mmol) of 4-(1-ethoxyethoxy)-1-(4-fluorophenyl)-2-butyn-l-ol in 50 ml of methylene chloride was added dropwise at 0° to a suspension of 95 g (1.1 mol) of manganese dioxide in 150 ml of methylene chloride. The reaction mixture was stirred at 0° for 10 minutes, filtered over magnesium sulphate and concentrated. Chromatography of the residue on 300 g of silica gel (elution agent ether/hexane 1:1) yielded 4 -(1-ethoxyethoxy)- 1-(4-fluorophenyl)-2-butyn- 1-one as an oil.

Provenance & Evidence