HCID 23050507, compound → HCID 23050495, compound

Participants

Reaction Steps

A solution of 7.6 g (29 mmol) of 4-(1-ethoxyethoxy)-1-(4-methoxyphenyl)-2-butyn-1-ol in 56 ml of methylene chloride was added dropwise at 0° to a suspension of 74 g (0.85 mol) of manganese dioxide in 100 ml of methylene chloride. The reaction mixture was stirred at 0° for 10 minutes, filtered over magnesium sulphate and concentrated. Chromatography of the residue on 300 g of silica gel (elution agent ether/hexane 1:1) Yielded 4-(1-ethoxyethoxy)- 1-(4-methoxyphenyl)-2-butyn-1-one as an oil.

Provenance & Evidence