HCID 23050444, compound → HCID 53975912, compound

Participants

Reaction Steps

A solution of 10.9 g (3B.9 mmol) of 4-(1-ethoxyethoxy)-1-[4-(methylthio)phenyl]-2-butyn-1-ol in 50 ml of methylene chloride was added dropwise at 0° to a suspension of 100 g (1.15 mol) of manganese dioxide in 170 ml of methylene chloride. The reaction mixture was stirred at 0° for 15 minutes, filtered over magnesium sulphate and concentrated. Flash chromatography of the residue on 200 g of silica gel (elution agent ether/hexane 1:1) yielded 4-(1 -ethoxyethoxy)1-[4-(methylthio)phenyl]-2-butyn-1-one as an oil.

Provenance & Evidence