HCID 23050481, compound → HCID 23050483, compound

Participants

Reaction Steps

A solution of 7.5 g (36 mmol) of methyl 4-(4-fluorophenyl)-4-hydroxy-2-butynoate in 100 ml of methylene chloride was added dropwise at 0° to a suspension of 89.3 g (1.03 mol) of manganese dioxide in 150 ml of methylene chloride. The reaction mixture was stirred at 0° for 30 minutes filtered over magnesium sulphate and concentrated. Crystallization of the residue from ether/hexane yielded methyl 3-(4-fluorobenzoyl)propiolate of melting point 62°-63°.

Provenance & Evidence