HCID 23050517, compound → HCID 23050484, compound

Participants

Reaction Steps

A solution of 13.8 g (55 mm ol) of methyl 4-(2,5-dimethoxyphenyl)-4-hydroxy-2-butynoate in 80 ml of methylene chloride is added dropwise at 0° to a suspension of 139 g (1.6 mol) of manganese dioxide in 350 ml of methylene chloride The reaction mixture was stirred at 0° for 1 hour, filtered over magnesium sulphate and concentrated. Crystallization of the residue from methylene chloride/ether yielded methyl 3-(2,5-dimethoxybenzoyl)propiolate of melting point 70°-71°.

Provenance & Evidence