HCID 23050458, compound → HCID 23050490, compound

Participants

Reaction Steps

A solution of 9.8 g (32 mmol) of 2-(2-methoxyethoxy)-ethyl 4-hydroxy-4-(4-methoxyphenyl)-2-butynoate in 100 ml of methylene chloride was added dropwise at 0° to a suspension of 83 g (0.95 mol) of manganese dioxide in 150 ml of methylene chloride. The reaction mixture was stirred at 0° for 2 hours, filtered over magnesium sulphate and concentrated. The residue was purified by flash chromatography on 800 g of silica gel (elution agent methylene chloride/ether 4:1). There was obtained 2-(2-methoxyethoxy)ethyl 3-(4-methoxybenzoyl)propiolate as a pale yellow oil.

Provenance & Evidence