Methyl 4-[2-benzenesulphonamidoindan-5-yl]-4-oxobutyrate → HCID 14071508, compound

HRID 1651860Notes

Reaction equation

HRID 1651860 reaction equation
[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=[O:27])[CH2:21][CH2:22][C:23]([O:25]C)=[O:24])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C>[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 14071507Methyl 4-[2-benzenesulphonamidoindan-5-yl]-4-oxobutyrate

Product 1

HCID 14071508HCID 14071508, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.7 ml of 15N sodium hydroxide solution are added to 8.3 g (21.4 mmol) of methyl 4-[2-benzenesulphonamido-indan-5-yl]-4-oxobutyrate in 20 ml of ethanol and the mixture is boiled for 2 hours. The mixture is evaporated in vacuo, the residue is taken up in water, and the reaction product is precipitated with hydrochloric acid. It is crystallised from ethyl acetate/diisopropyl ether.

Workup

  1. customThe mixture is evaporated in vacuo
  2. customthe reaction product is precipitated with hydrochloric acid
  3. customIt is crystallised from ethyl acetate/diisopropyl ether

Sources & evidence

ORD record
ord-abf328c87e334004931a15a27a7f45d3
Source dataset
uspto-grants-1990_05
Patent number
US04929754

Reaction notes

Loading…