4-Chloro-2-fluoro-5-isopropoxyphenyl isocyanate → HCID 54186947, compound

HRID 1653628Notes

Reaction equation

HRID 1653628 reaction equation
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH:9]=[CH:8][CH2:7][NH:6]1)=[O:4].[Cl:11][C:12]1[C:17]([O:18][CH:19]([CH3:21])[CH3:20])=[CH:16][C:15]([N:22]=[C:23]=[O:24])=[C:14]([F:25])[CH:13]=1>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH:9]=[CH:8][CH2:7][N:6]1[C:23]([NH:22][C:15]1[CH:16]=[C:17]([O:18][CH:19]([CH3:20])[CH3:21])[C:12]([Cl:11])=[CH:13][C:14]=1[F:25])=[O:24])=[O:4]

Participants

4

Reactant 2

HCID 132729244-Chloro-2-fluoro-5-isopropoxyphenyl isocyanateHCID 45089941HCID 45089941, compound

Product 1

HCID 54186947HCID 54186947, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

To a stirred solution of 5,65 g (0,04 moles) of 1,2,3,6-tetrahydro-2-pyridinecarboxylic acid methyl ester in 75 ml of dry toluene are added dropwise without cooling 9,2 g (0,04 moles) of 4-chloro-2-fluoro-5-isopropoxyphenyl isocyanate, dissolved in 200 ml of dry toluene.

Sources & evidence

ORD record
ord-de2c882505a1479bb68526f0cbf949a3
Source dataset
uspto-grants-1995_04
Patent number
US05403817

Reaction notes

Loading…