反应详情

温度

100 °C

3.0 g (9.8 mmol) of methyl 6-amino-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]picolinate, 1.5 g (10.8 mmol) of 2-butenyl bromide and 1.6 g (11.8 mmol) of potassium carbonate were added to 10 ml of DMF, and the mixture was stirred at 100° C. for one hour. After completion of the reaction, the reaction mixture was poured into water, then extracted with ethyl acetate, dried and concentrated. Then, the obtained residue was purified by column chromatography and crystallized to obtain a solid, which was washed with diisopropyl ether to obtain the desired product as colorless prism crystals.

1. customAfter completion of the reaction
2. extractionextracted with ethyl acetate
3. customdried
4. concentrationconcentrated
5. customThen, the obtained residue was purified by column chromatography
6. customcrystallized
7. customto obtain a solid, which
8. washwas washed with diisopropyl ether