beta-Cyclodextrin → HCID 178473453, compound

Participants

Reaction Steps

6.6 g of β-cyclodextrin (5 mmoles, content 14%) and 0.6 g (2.5 mmoles) of Molsidomin are homogenized in a friction mortar protected from light if possible. 3 ml of a 50% ethyl alcohol are added and the dense suspension is stirred for further 30 minutes after spreading the product of hard lubricity and paste like consistence on a watch-glass, it is dried to constant weight in the presence of phosphoruspentoxide in an exsiccator. The product obtained is pulverized, its active ingredient content is 9±0.5% determined by the spectrophotometric method, which corresponds to a molar ratio of about 1:2. DSC curves of Molsidomin, its mechanical mixture and its complex with β-CD are significantly different. The endothermic peak at 140°-142° C. on the DSC curve completely disappeared in the case of complexes with β-CD prepared by both kneading or liophylization. It indicates that the Molsidomin is complexed, and at 130°-160° C. temperature range not even a 50 fold magnified curve showed endothermic peak of melting in the case of complex prepared by lyophilization.

Provenance & Evidence