Trifluoroacetic acid → 1,4,5,6-Tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine trifluoroacetate

HRID 1653712노트

반응식

HRID 1653712 반응식
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH2:13][CH:12]([C:14]3[O:18][N:17]=[C:16]([CH3:19])[N:15]=3)[CH2:11][N:10]=[CH:9]2)C=CC=CC=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[CH3:19][C:16]1[N:15]=[C:14]([CH:12]2[CH2:13][NH:8][CH:9]=[N:10][CH2:11]2)[O:18][N:17]=1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 100244281-Triphenylmethyl-1,4,5,6-tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine

생성물 1

HCID 98385801,4,5,6-Tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine trifluoroacetate수율 62%

실험 절차

1-Triphenylmethyl-1,4,5,6-tetrahydro-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidine (254 mg, 0.6 mmol) is dissolved in trifluoroacetic acid (TFA) (1 mL) with stirring at room temperature for 24 hours. The dark solution is then evaporated in vacuo, and the residue recrystallized from methanol/ether to yield 105 mg (62%) white crystals, mp 120°-122° C. identified by 300 MHz nmr. Calculated: C 38.57, H 3.96, N 19.99; found: C 38.72, H 4.09, N 19.78.

후처리

  1. customThe dark solution is then evaporated in vacuo
  2. customthe residue recrystallized from methanol/ether

출처 및 근거

ORD 기록
ord-7b6b6c7fcb484780847907858e330cb0
출처 데이터셋
uspto-grants-1995_04
특허 번호
US05403845

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