HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran → 4-[3-(7-Fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran | HCID 20080618 | — |
| Reactant | 2-(Bromomethyl)-7-fluoronaphthalene | HCID 23292295 | — |
| Product | 4-[3-(7-Fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyran | HCID 20080672 | 77% |
Reaction Steps
Using the procedure described in Example 5, 7-fluoro-2-bromomethylnaphthalene (0.5 g) was reacted with 4-(3-hydroxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran (0.45 g, more polar isomer) to give 4-[3-(7-fluoronaphth-2-ylmethoxy)phenyl]-4-methoxy-2,6-dimethyltetrahydropyran (0.74 g, 77%), as an oil which crystallised on standing, m.p. 77° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05403859 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-47c9a1f9bb614ba2a5c790b6cb5f9212 |
| Source note | uspto-grants-1995_04 |