Methyl iodide → 4-(3-Benzyloxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran

Participants

Reaction Steps

Using the procedure described in Example 3, the more polar isomer of 4-(3-benzyloxyphenyl)-4-hydroxy-2,6-dimethyltetrahydropyran (described in the portion of Example 52 which is concerned with the preparation of starting materials) was reacted with methyl iodide to give 4-(3-benzyloxyphenyl)-4-methoxy-2,6-dimethyltetrahydropyran, (77%, more polar isomer), as an oil.

Provenance & Evidence