Thionyl Chloride → HCID 15344573, compound

HRID 1653802Notes

Reaction equation

HRID 1653802 reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:21]2[O:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[C:18]([CH3:28])[C:17](=[O:29])[C:16]=2[CH:15]=[CH:14][CH:13]=1)=[O:11]>C(Cl)(Cl)Cl>[Cl:3][CH2:6][CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:21]2[O:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[C:18]([CH3:28])[C:17](=[O:29])[C:16]=2[CH:15]=[CH:14][CH:13]=1)=[O:11]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15344572HCID 15344572, compound

Product 1

HCID 15344573HCID 15344573, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A solution of 1.1 ml of thionyl chloride in 2 ml of chloroform was added to a boiling solution of 3.37 g of Intermediate XXXVI in 20 ml of chloroform. After stirring for 90 minutes under reflux, the solvent was removed in vacuo and the residue was crystallized from acetonitrile to give 3 g of pure title compound, m.p. (188) 193°-194° C.

Workup

  1. temperatureunder reflux
  2. customthe solvent was removed in vacuo
  3. customthe residue was crystallized from acetonitrile

Sources & evidence

ORD record
ord-1f2cbf43c2614b2cbae6c1dea6cb98dc
Source dataset
uspto-grants-1995_04
Patent number
US05403842

Reaction notes

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