HCID 20080525, compound → HCID 20080519, compound

Participants

Reaction Steps

45 g of 2-acetylamino-1-(4-chlorophenyl)-2-(4-methoxyphenyl)ethanone, dissolved in 300 cm3 of ethanol containing 135 cm3 of hydrochloric acid (d=1.18), are heated to reflux for 7 hours. After filtration through kieselguhr and concentration to dryness under vacuum, 200 cm3 of acetone are added to the solid residue, which is drained and washed with the same solvent, twice 75 cm3. 36 g (80%) of 2-amino-1-(4-chlorophenyl)-2-(4-methoxyphenyl)ethanone hydrochloride, an amorphous white powder, melting point 230° C., are obtained.

Provenance & Evidence