反应详情

温度

4 °C

To 70 ml of ethanol were added 24.39 g of (-)-(S)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane and 27.3 g of fumaric acid and the mixture was heated to prepare a homogeneous solution. The solution was allowed to cool and maintained at 4° C. for about 15 hours. The resulting crystals were collected by filtration and dried under reduced pressure to give 47 g of (-)-(S)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane sesquifumarate.

1. temperaturethe mixture was heated
2. customto prepare a homogeneous solution
3. temperatureto cool
4. filtrationThe resulting crystals were collected by filtration
5. customdried under reduced pressure