2,8-Dimethyl-3-methylene-1-oxa-8-azaspiro(4,5)decane → (-)-(S)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane L-tartrate monohydrate

Participants

Reaction Conditions

Reaction Steps

To 90% aqueous ethanol (water:ethanol =1:9, v/v), 7 g of (±)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane and 5.79 g of L-tartaric acid were added and dissolved by heating at 60° C. The resulting solution was allowed to cool and maintained at about 4° C. for 15 hours. The resulting crystals were collected by filtration and, without drying, recrystallized from 9 ml of 90% aqueous ethanol. This recrystallization procedure was repeated further twice and the crystals obtained were dried under reduced pressure to give 3.22 g of (-)-(S)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4.5]decane L-tartrate monohydrate.

Provenance & Evidence