Methylamine → HCID 20080815, compound

Participants

Reaction Steps

3-(4-Chlorophenyl)-2,6-dimethylpyran-4-one (2.27 g) was heated at 150° with a solution of methylamine in ethanol (35 ml; 33% w/w) in an autoclave for 12 hr. The mixture was concentrated in vacuo, triturated with ether and filtered, to afford the title compound (1.2 g), m.p. 221°-222°, NMR δH (d6 -DMSO) 7.42 (2H, d, J 5 Hz), 7.1 (2H, d, J 5 Hz), 6.1 (1H, s), 3.5 (3H, s), 2.32 (3H, s), 2.15 (3H, s).

Provenance & Evidence