Ammonia → HCID 20080781, compound

Participants

Reaction Steps

3-(4-(4-Trifluoromethoxyphenoxy)phenyl)-2,6-dimethylpyran-4-one (4.1 g) was dissolved in ethanol (10 ml) and heated in a stainless steel autoclave with 0.880 ammonia (35 ml) at 150° for 24 hr. After cooling the crystalline precipitate was filtered off, washed with ethyl acetate and dried in vacuo to afford the title compound (2.78 g), m.p. 244°-248°, NMR δH (d6 -DMSO) 11.1 (1H, br. s) 7.4 (2H, m), 7.1-7.3 (4H, m), 7.02 (2H, m), 5.95 (1H, s), 2.2 (3H, s), 2.08 (3H, s).

Provenance & Evidence