Water → HCID 20080846, compound

Participants

Reaction Steps

To a stirred suspension of 3-Chloro-5-(4-(4-trifluoromethoxyphenoxy)phenyl)-2,6-dimethyl pyridin-4(1H)-one (0.41 g) in dry DMF, under nitrogen, was added all at once sodium hydride (0.05 g of a 60% dispersion in mineral oil). After stirring at rt for 30 min acetyl chloride (0.14 ml) was added. The mixture was stirred at rt for a further 2 hr, poured into iced water, extracted with ether, washed with water and satd. aq. sodium bicarbonate and dried over magnesium sulphate. Evaporation gave an oil which was triturated with hexane to give the title compound (0.2 g), m.p. 78°-80°, Nmr δH (CDCl3) 7.3-7.0 (8H, m), 2.68 (3H, s), 2.35 (3H, s), 2.05 (3H, s).

Provenance & Evidence