HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Isobutyl 2-hydroxy-5-iodobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Isobutanol | HCID 6560 | — |
| Reactant | 5-Iodosalicylic acid | HCID 8388 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Isobutyl 2-hydroxy-5-iodobenzoate | HCID 19423370 | — |
Reaction Steps
2-hydroxy-5-iodobenzoic acid (477 g, 1.8 mol), isobutanol (225 g), conc sulfuric acid (20 ml) in toluene (2 l) was refluxed for 6 h using a water separator. The solution was cooled and washed with water. The solution was treated with decolorizing carbon and the toluene was evaporated. The residue was recrystallized from methanol. Yield 376 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05403930 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-aba77bbe47544df3878f92ebd14df2b7 |
| Source note | uspto-grants-1995_04 |