Water → 2-Hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]acetyl]benzoic acid

HRID 1653914Notes

Reaction equation

HRID 1653914 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][C:16]([S:19]([NH:22][C:23]3[C:28]([CH3:29])=[CH:27][CH:26]=[CH:25][N:24]=3)(=[O:21])=[O:20])=[CH:15][CH:14]=2)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH2:30]>C(O)=O>[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11](=[O:30])[CH2:12][C:13]2[CH:14]=[CH:15][C:16]([S:19]([NH:22][C:23]3[C:28]([CH3:29])=[CH:27][CH:26]=[CH:25][N:24]=3)(=[O:21])=[O:20])=[CH:17][CH:18]=2)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 962WaterHCID 3086668Susalimod

Product 1

HCID 194234092-Hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]acetyl]benzoic acidYield 71%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoic acid (4.1 g, 0.01 mol) in formic acid (100 ml) was refluxed for 30 h. Water (200 ml) was added and the product crystallized to yield 3.0 g (71% ) product.

Workup

  1. customthe product crystallized

Sources & evidence

ORD record
ord-d4dbd92320174cb4ab0f0c54d83fe846
Source dataset
uspto-grants-1995_04
Patent number
US05403930

Reaction notes

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