Sulfuryl chloride → 3-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

HRID 1653956Notes

Reaction equation

HRID 1653956 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4].S(Cl)([Cl:18])(=O)=O>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[C:9]([Cl:18])=[C:8]([O:10][CH:11]([F:13])[F:12])[N:7]([CH3:14])[N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 54319416Methyl 5-(difluoromethoxy)-1-methyl-1H-pyrazole-3-carboxylate

Product 1

HCID 537351233-Methoxycarbonyl-4-chloro-5-difluoromethoxy-1-methylpyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2.1 g (10 mmole) 3-Methoxycarbonyl-5-difluoromethoxy-1-methylpyrazole, dissolved in 30 ml methylene chloride, was treated with 1.35 g (10 mmole) sulfuryl chloride and stirred for 10 minutes at room temperature. It was then concentrated and recrystallised from diisopropyl ether/ethyl acetate.

Workup

  1. concentrationIt was then concentrated
  2. customrecrystallised from diisopropyl ether/ethyl acetate

Sources & evidence

ORD record
ord-d78eb459e7e040cb96afc783a6311d26
Source dataset
uspto-grants-1995_04
Patent number
US05405829

Reaction notes

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