Acetic Anhydride → HCID 15676673, compound

HRID 1653987Notes

Reaction equation

HRID 1653987 reaction equation
[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:7]=[N:8][C:9]([C:15]2[NH:16][C:17](=[O:24])[C:18]([CH:21]([CH3:23])[CH3:22])([CH3:20])[N:19]=2)=[C:10]([CH:14]=1)[C:11](O)=[O:12].C(OC(=O)C)(=O)C>C1(C)C=CC=CC=1>[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:14]=[C:10]2[C:11](=[O:12])[N:19]3[C:18]([CH:21]([CH3:23])[CH3:22])([CH3:20])[C:17](=[O:24])[N:16]=[C:15]3[C:9]2=[N:8][CH:7]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 15672410HCID 15672410, compound

Product 1

HCID 15676673HCID 15676673, compoundYield 117.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

5-(1,3-Dioxolan-2-yl)-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (10.02 g, 0.03 mol) and acetic anhydride in toluene is heated at reflux temperature for 5 hours. Concentration in vacuo gives the title compound as an orange solid (11.10 g, 100%), mp 146°-148° C., identified by IR and NMR spectral analyses.

Workup

  1. temperatureat reflux temperature for 5 hours
  2. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-901e1d4a81f447008892730271dae89e
Source dataset
uspto-grants-1995_04
Patent number
US05405827

Reaction notes

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