Indan-5-amine → HCID 15053109, compound

HRID 1654053Notes

Reaction equation

HRID 1654053 reaction equation
F[C:2]1[CH:3]=[N+:4]([O-:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[CH2:12]1[C:20]2[C:15](=[CH:16][C:17]([NH2:21])=[CH:18][CH:19]=2)[CH2:14][CH2:13]1>C(O)C.CCOCC>[CH2:12]1[C:20]2[C:15](=[CH:16][C:17]([NH:21][C:2]3[CH:3]=[N+:4]([O-:11])[CH:5]=[CH:6][C:7]=3[N+:8]([O-:10])=[O:9])=[CH:18][CH:19]=2)[CH2:14][CH2:13]1

Participants

5

Reactant 2

HCID 90496Indan-5-amineHCID 5940283-Fluoro-4-nitropyridin-1-ium-1-olate

Product 1

HCID 15053109HCID 15053109, compoundYield 93.3%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of 3-fluoro-4-nitropyridine-1-oxide (12 g) and indan-5-amine (10 g) in 200 ml ethanol was stirred at reflux for two hours, and thereafter cooled, diluted with ether and filtered to give 19 g solid, m.p. 195°. Four grams were recrystallized from ethanol to give 2.6 g crystals, m.p. 194°-195°.

Workup

  1. temperatureat reflux for two hours
  2. temperaturecooled
  3. filtrationfiltered

Sources & evidence

ORD record
ord-5f0829e266424ce8a6d292ef62ee5b3e
Source dataset
uspto-grants-1995_04
Patent number
US05405856

Reaction notes

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