HCID 20079497, compound → HCID 15053114, compound

Participants

Reaction Steps

A suspension of 1-acetyl-2,3-dihydro-N-(4-nitro-3-pyridinyl)-1H-indole-5-amine, N5 -oxide (13 g) in 250 ml ethanol containing 0.5 g PtO2 was hydrogenated for two days at 60 psi and thereafter filtered through Celite and concentrated to 9 g solid. This solid was purified by HPLC (silica, 20% methanol in ethyl acetate) to give 4 g solid. This was combined with 1 g product obtained from a previous reduction and again purified by HPLC (silica, 20% methanol in ethyl acetate) to give 5 g solid, m.p. 210°-212°. This solid was recrystallized from acetonitrile to give 4 g solid, m.p. 212°-214°.

Provenance & Evidence