Ethanol → HCID 86744476, compound

HRID 1654067Notes

Reaction equation

HRID 1654067 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][N+:7]([O-])=[CH:6][C:5]=1F)([O-:3])=[O:2].[NH2:12][C:13]1[CH:14]=[C:15]2[C:19](=[C:20]([Cl:22])[CH:21]=1)[NH:18][C:17]([CH3:23])=[C:16]2[CH3:24].C([OH:27])C>>[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[NH+:12]([O-:27])[C:13]1[CH:14]=[C:15]2[C:19](=[C:20]([Cl:22])[CH:21]=1)[NH:18][C:17]([CH3:23])=[C:16]2[CH3:24])([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 702EthanolHCID 5940283-Fluoro-4-nitropyridin-1-ium-1-olateHCID 15135741HCID 15135741, compound

Product 1

HCID 86744476HCID 86744476, compound

Conditions

Temperature
50 °C

Procedure

A mixture of 4-nitro-3-fluoropyridine N-oxide (1.2 g) and 5-amino-7-chloro-2,3-dimethylindole (1.4 g) in thoroughly degassed absolute ethanol was stirred at 50° C. for 30 minutes and thereafter cooled slowly to 0° C. The precipitate was collected and air-dried to give 2.37 g of N-(4-nitro-3-pyridinyl)-7-chloro-2,3-dimethyl-1H-indol-5-amine N5 -oxide as a powder.

Workup

  1. temperaturecooled slowly to 0° C
  2. customThe precipitate was collected
  3. customair-dried

Sources & evidence

ORD record
ord-85a8795be56345bbbdcbef40605ca111
Source dataset
uspto-grants-1995_04
Patent number
US05405856

Reaction notes

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