Dichloroacetic Acid → HCID 9827187, compound

Participants

Reaction Steps

To a solution of 2-(8-formyl-1-oxo-3-phenyl-1,2-dihydropyrido[3,4-b]indol-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (0.1 g) in dimethylsulfoxide (1 mL) and toluene (1 mL) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.46 g) and dichloroacetic acid (0.I mL). The resulting solution was allowed to stir for 2 hours. The mixture was poured into ethyl acetate, washed (1N hydrochloric acid, H2O), dried, and evaporated. The resulting material was chromatographed, with ether:ethyl acetate (gradient, 1:1, 0:1) as the eluent, to give the title compound (0.1 g) as a white solid; TLC: Rf =0.5, methanol:dichloromethane (5:95); 300 MHz.

Provenance & Evidence