Dichloroacetic Acid → HCID 20079371, compound

Participants

Reaction Steps

To a solution of 2-(8-ethoxycarbonyl-1,2-dihydropyrido[3,4-b]indol-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide (0.57 g) in dimethyl sulfoxide (6 mL) and toluene (6 mL) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (2.3 g) and dichloroacetic acid (0.43 mL) and the resulting solution allowed to stir for 2 hours. The reaction mixture was poured into ethyl acetate, washed (1N hydrochloric acid, H2O), dried, and evaporated. The resulting material was purified by chromatography, with methanol:dichloromethane (3:97) as the eluent. The resulting solid was recrystallized from ethyl acetate to give the title compound (0.41 g); mp 218°-219° C.

Provenance & Evidence