HCID 20079369, compound → HCID 20079378, compound

HRID 1654077Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]1[CH2:13][N:14]([CH2:17][C:18]([NH:20][CH:21]([CH:28]([CH3:30])[CH3:29])[CH:22]([OH:27])[C:23]([F:26])([F:25])[F:24])=[O:19])[CH:15]=[CH:16][C:9]2=1)([OH:3])=O.C(OC(C1C=CC=C2C=1[NH:43]C1CN(CC(NC(C(C)C)C(O)C(F)(F)F)=O)C=CC2=1)=O)C>>[C:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][C:10]1[CH2:13][N:14]([CH2:17][C:18]([NH:20][CH:21]([CH:28]([CH3:29])[CH3:30])[C:22](=[O:27])[C:23]([F:26])([F:25])[F:24])=[O:19])[CH:15]=[CH:16][C:9]2=1)(=[O:3])[NH2:43]

Participants

Reactant 2

HCID 20079369HCID 20079369, compound

HCID 20079376HCID 20079376, compound

Product 1

HCID 20079378HCID 20079378, compound

Procedure

2-(8-Carboxy-1,2-dihydropyrido[3,4-b]indol-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide. 2-(8-Ethoxycarbonyl-1,2-dihydropyrido[3,4-b]indol-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide was subjected to a hydrolysis procedure similar to that outlined in Example 3 to give the title compound as a white solid;

Sources & evidence

ORD record: ord-1f1097733e7a4dddb9df8678e7161754
Source dataset: uspto-grants-1995_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05405852

Reaction notes

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