8-methoxyquinolin-5-amine → HCID 20079050, compound

HRID 1654084Notes

Reaction equation

HRID 1654084 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.Cl[CH2:15][CH:16]([OH:37])[CH2:17][N:18]1[CH2:23][CH2:22][N:21]([CH:24]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:20][CH2:19]1>>[C:31]1([CH:24]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:21]2[CH2:20][CH2:19][N:18]([CH2:17][CH:16]([OH:37])[CH2:15][NH:1][C:2]3[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]4[C:3]=3[CH:4]=[CH:5][CH:6]=[N:7]4)[CH2:23][CH2:22]2)[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 5894668-methoxyquinolin-5-amineHCID 103601754-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine

Product 1

HCID 20079050HCID 20079050, compoundYield 11.6%

Procedure

Following the same procedure as in Example 27, reaction and treatment were carried out using 1.81 g of 5-amino-8 methoxyquinoline and 1.23 g of 4-(3-chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine to obtain 200 mg of 5-[3-(4-diphenylmethylpiperazine- 1-yl)-2-hydroxy-propylamino]-8 methoxyquinoline.

Workup

  1. customas in Example 27, reaction and treatment

Sources & evidence

ORD record
ord-52882fc05e4d4239996af1eade8b5fc2
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

Loading…