4-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazine → 5-[3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropylthio]quinoline

HRID 1654086Notes

Reaction equation

HRID 1654086 reaction equation
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([SH:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl[CH2:13][CH:14]([OH:35])[CH2:15][N:16]1[CH2:21][CH2:20][N:19]([CH:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:18][CH2:17]1>>[C:29]1([CH:22]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:19]2[CH2:18][CH2:17][N:16]([CH2:15][CH:14]([OH:35])[CH2:13][S:11][C:6]3[CH:7]=[CH:8][CH:9]=[C:10]4[C:5]=3[CH:4]=[CH:3][CH:2]=[N:1]4)[CH2:21][CH2:20]2)[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 103601754-(3-Chloro-2-hydroxypropyl)-1-diphenylmethylpiperazineHCID 1357553243056-03-9

Product 1

HCID 152281355-[3-(4-Diphenylmethylpiperazine-1-yl)-2-hydroxypropylthio]quinolineYield 20.3%

Procedure

Following the same procedure as in Example 23-(c), reaction and treatment were carried out using 220 mg of 5-quinolinethiol and 1.2 g of 4-(3-chloro-2-hydroxypropyl)-1-(diphenylmethyl)piperazine, in order to obtain 130 mg of 5-[3-(4-diphenylmethylpiperazine-1-yl)-2-hydroxyProPylthio]quinoline.

Workup

  1. customas in Example 23-(c), reaction and treatment

Sources & evidence

ORD record
ord-8cf9ff785e5b409da86cdf46b0191eb4
Source dataset
uspto-grants-1995_04
Patent number
US05405843

Reaction notes

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