反应详情

温度

-60 °C

20 g of the product of Stage B were cooled to -60° C. in 200 ml of toluene, 160 ml of diisobutylaluminium hydride were added dropwise. The mixture was stirred for 1 and a half hours at -60° C. and was then poured into sodium potassium double tartrate and extracted with methylene chloride. The solvent was evaporated and the residue was chromatographed on silica (eluent: 7/3 hexane/ethyl acetate) to obtain 16 g of the expected product.

1. extractionextracted with methylene chloride
2. customThe solvent was evaporated
3. customthe residue was chromatographed on silica (eluent: 7/3 hexane/ethyl acetate)