HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbenzenesulfonic acid → Ethyl 5-methyl-2-(trifluoromethyl)furan-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbenzenesulfonic acid | HCID 6925 | — |
| Reactant | Ethyl 4-oxo-2-(2,2,2-trifluoroacetyl)pentanoate | HCID 10933598 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 5-methyl-2-(trifluoromethyl)furan-3-carboxylate | HCID 2737208 | 60.8% |
Reaction Steps
24 g of the product of Stage A were mixed in 150 ml of toluene and 1.85 g of toluenesulfonic acid were added. The mixture was refluxed for 20 hours. The solvent was evaporated under reduced pressure at 40° C. The residue was chromatographed on silica (eluent: 95/5 hexane/ethyl acetate) to obtain 13.5 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05405865 |
| Source dataset | uspto-grants-1995_04 |
| ORD ID | ord-4cfcf421f758470dac7cf27517bde940 |
| Source note | uspto-grants-1995_04 |