Dichloromethane → HCID 20079678, compound

Participants

Reaction Steps

The mixture of approximately 1.78 g of the product of Stage D and approximately 20 ml of methylene chloride was cooled to +5° C. and 27 ml of ethynylmagnesium bromide as a 0.5M solution in tetrahydrofuran were added over 15 minutes. The mixture was stirred for 15 minutes at +5° C., poured into an aqueous sodium dihydrogenphosphate solution and extracted with methylene chloride. The extract was dried, the solvent was evaporated at 30° C. and the residue was chromatographed on silica (eluent: methylene chloride) to obtain 0.87 g of the expected product.

Provenance & Evidence