Sodium Hydroxide → HCID 178435419, compound

HRID 1654149Notes

Reaction equation

HRID 1654149 reaction equation
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[C:17][Si](C)(C)C)=[C:9]([F:22])[CH:8]=2)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>CO>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[CH:17])=[C:9]([F:22])[CH:8]=2)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178441851HCID 178441851, compound

Product 1

HCID 178435419HCID 178435419, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 1.0 g of 2-butyl-7-fluoro-6-[(trimethylsilyl)ethynyl]-4(1H)-quinazolinone, 20 ml of 1N sodium hydroxide and 25 ml of methyl alcohol is heated at 60° C. for 5 hours then evaporated in vacuo. The residue is dissolved in 100 ml of water and acidified. The resulting solid is collected and dried to afford 700 mg of the desired product as a yellow solid, m.p. 218° C.

Workup

  1. customthen evaporated in vacuo
  2. dissolutionThe residue is dissolved in 100 ml of water
  3. customThe resulting solid is collected
  4. customdried

Sources & evidence

ORD record
ord-912e028cf6e54298937ff968dfabb8e1
Source dataset
uspto-grants-1995_04
Patent number
US05405849

Reaction notes

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