Benzenemethanethiol, alpha,alpha-diphenyl- → HCID 20079589, compound

Participants

Reaction Steps

To a solution of trityl mercaptan (9.7 g, 35 mmol) in ethanol (90 ml) was added, at 0° C., a sodium methoxide-methanol solution (28%) (7.1 ml). To the reaction mixture was added 1-(2-chloroethyl)benzimidazole (6.32 g, 35 mmol), which was heated for 2 hours under reflux. Insoluble substances were filtered off, and the filtrate was concentrated under reduced pressure. The concentrate was subjected to a silica gel column chromatography (3.0×40 cm: ethyl acetate:hexane=1:1→2:1) to give 1-(2-tritylthioethyl)benzimidazole (5.6 g, 38%).

Provenance & Evidence