Thionyl Chloride → HCID 20079581, compound

Participants

Reaction Steps

To thionyl chloride (7.0 ml) was gradually added 2-hydroxymethyl-1-(2,2,3,3-tetrafluoropropyl)imidazole (0.70 g) at 0° C., and the mixture was refluxed for 45 minutes. The reaction mixture was concentrated under reduced pressure, to which was added diethyl ether, then precipitating crystals were collected by filtration. The crystals were dissolved in ethanol, followed by recrystallization from diethyl ether to give 2-chloromethyl-1-(2,2,3,3-tetrafluoropropyl)imidazole hydrochloride (0.90 g) as colorless needles, m.p. 104°-107° C.

Provenance & Evidence