反应详情

To thionyl chloride (2.0 ml) was added at 0° C. 3-hydroxymethyl-4-methyl-4H-1,2,4-triazole (0.15 g), and the mixture was refluxed for 1.5 hour. The reaction mixture was concentrated under reduced pressure, to which was added diethyl ether. Resulting crystals were collected by filtration and dissolved in ethanol, to which was added diethyl ether for recrystallization to afford 3-chloromethyl-4-methyl-4H-1,2,4-triazole hydrochloride (0.22 g) as colorless prisms, m.p. 96°-97° C.

1. concentrationThe reaction mixture was concentrated under reduced pressure, to which
2. additionwas added diethyl ether
3. customResulting crystals
4. filtrationwere collected by filtration
5. dissolutiondissolved in ethanol, to which
6. additionwas added diethyl ether
7. customfor recrystallization