Formaldehyde → HCID 20079585, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6,7-dihydro-5H-pyrrolo[1,2-c]imidazole (7 g) and paraformaldehyde (4 g) was heated at 160° C., to which was added, 20 minutes later, paraformaldehyde (2 g), and, further 20 minutes later, paraformaldehyde (1 g), followed by heating for 45 minutes. The reaction mixture was subjected to a silica gel chromatography (4.0 cm×15 cm), eluting with methanol-methylene chloride (1:9). The object fraction was concentrated. To the concentrate were added ethanol and diethyl ether to give 6,7-dihydro-3-hydroxymethyl-5H-pyrrolo[1,2-c]imidazole (3.4 g) as colorless needles, m.p. 110°-120° C.

Provenance & Evidence