反应详情

In methylene chloride (300 ml) was dissolved 2',4'-difluoropropiophenone (55 g), to which was added bromine (50 g) dropwise, while stirring, during 30 minutes. The mixture was stirred for 30 minutes at room temperature. To the reaction mixture was added water (200 ml), and the methylene chloride layer was washed three times, followed by drying over anhydrous magnesium sulfate. The solvent was distilled off to leave 2-bromo-2',4'-difluoropropiophenone (77 g) as a pale yellow oily product.

1. stirringThe mixture was stirred for 30 minutes at room temperature
2. washthe methylene chloride layer was washed three times
3. dry with materialby drying over anhydrous magnesium sulfate
4. distillationThe solvent was distilled off